Ihe na ihe kpatara Yohimbine
N'ime afọ ole na ole gara aga, Yohimbine bụ isiokwu nke ọtụtụ arụmụka kpụ ọkụ n'ọnụ n'etiti ndị na-ahụ maka ụlọ ọrụ na ndị na-anụ ahụ ike.
Ọ bụrụ na ị na-achọ ọgwụ na-eme ka ọrụ na-aga n'ihu nke nwere ike inyere gị aka inweta ahụ ike ma tufuo abụba ka ị na-emeziwanye arụmọrụ gị n'ime ime ụlọ, ọ bụ oge na ị ga-agụkwu banyere ọgwụ dị ịtụnanya a maara dị ka Yohimbine.
Yohimbine, indole alkaloid sitere na ogbugbo nke Central African Yohimbe osisi, amaara maka inye ọtụtụ uru. Ọ nwere ọrụ dị ka onye na-anabata dopamine D2 antagonist, serotonergic antagonist, na alpha-adrenergic antagonist.
Nkà ọgwụ
Yohimbine nwere ike ịkọwa nke ọma dị ka indolalkylamine alkaloid na kemịkal kemịkalụ na nke Respine. O nwere ikike igbochi presynaptic alpha-2 adrenergic receptors. Mmetụta ụbụrụ autonomic dị n'akụkụ nke Yohimbine bụ iji belata ọmịiko (adrenergic) ma mụbaa ọrụ parasympathetic (cholinergic).
Yohimbine makwaara igbochi alpha-1 na alpha-2 adrenoceptors. Site n'ime nke a, ọ na - akpali mmụba na adrenaline na dopamine ma belata ogo serotonin. Nke a, n’aka nke ya, na-enye aka na ntọhapụ nke insulin na mbelata shuga shuga. A makwa ọgwụ a na-egbochi dopamine-2 na dopamine-3 (D2 na D3) ndị nnabata na serotonin-1B, -1D, -2A, na -2B (5-HT1B, 5-HT1D, 5-HT2A, na 5- HT2B) ndị nnata.
Okwesiri ighota ebe a na nmekorita nke nwoke na nwoke na nwanyi nwere mmekorita ya na oru nkpuchi nke adresergic nke na eme ka onu ogugu (ma obu abuo). Yohimbine na-arụ ọrụ dị mma na ikike erectile site na imepụta mmụba dị ukwuu na ọmịiko nke ọmịiko nke abụọ maka ntọhapụ na norepinephrine. O nwekwara ikike kpalie ọnụ ọgụgụ nke mkpụrụ ndụ na isi noradrenergic nke ụbụrụ.
Yohimbine na abụba abụba
Yohimbine bụ onye a ma ama na ndị egwuregwu na ndị na-eme egwuregwu n'oge oge mgbanwe SARM n'ihi ike ya dị ka ọgwụ na-ebu ibu.
Ndị na-anabata Alpha-2 bụ ndị a na-ahụkarị na saịtị ahụ nke na-agbakọta abụba ọkacha mma: apata ụkwụ, ara, afọ, na buttocks. Alfa-2 ebe nnabata mgbe ekpughere ka ha na-ekesa catecholamines dị ka epinephrine na norepinephrine na-egbochi ntọhapụ nke acid fatty (lipolysis) ebe ndị nabatara beta na-akpali lipolysis.
N'ụzọ bụ isi, mwepụta nke abụba abụba sitere na anụ ahụ dị na ọbara na-akpali site na glucagon, adrenocorticotropic hormone (ACTH), epinephrine, norepinephrine, na hormone nke na-eto eto. Fatty acids dị n'ọbara na-adịkarị ngwa ngwa ma ọ bụrụ na ọnụọgụ ọbara fatty acid adịghị elu site na ntinye fatty acid nke na-eme na nri.
Ọ na - abụkarị, abụba ọbara ọbara na - amasị nchekwa abụba mgbe ọ dị elu nke na - apụta site na arụghị ọrụ na iri nri. N'ikwu okwu n'ụzọ doro anya, igbochi ndị nabatara alpha-2 na-egosi na ọ bara uru maka ịhapụ catecholamines dị ka norepinephrine n'oge ọnwụ dị arọ nke na-eme ka ọ dịkwuo maka saịtị ndị na-akpali akpali nke beta nke na-ebute ọnụọgụ dị elu nke lipolysis. Yohimbine site na alpha 2-adrenergic receptor antagonist na-eme ka ọkwa norepinephrine dị n'ọbara.
Ogwu ogwu Yohimbine
Yohimbine dị oke irè ma a bịa n'ịgwọ adịghị ike. Nke a bụ otu n'ime ihe ndị kachasị mere eji egosi Yohimbine dị ka onye nwere ọmịiko na mydriatic maka ndị nwoke nwere ọrịa vaskụla ma ọ bụ psychogenic na mmalite nke ọrịa shuga. Yohimbine a na-egosikwa maka ịgwọ nsogbu mmekọahụ nke nwoke na nwanyị.
Ojiji nke Mmeju Yohimbine jikọtara ya na mmụba dị ịrịba ama na ọkwa nke ọnwụ, arụmọrụ egwuregwu, ọbara mgbali, na ọbara na-agbanye n'ahụ. A na-ejikwa ya agwọ ọtụtụ nsogbu ahụike gụnyere gụnyere mana ejedebeghị ehighị ụra nke ọma, oke ibu, syncope, mgbaka, nsogbu ọria mamari, na enweghi ike nwoke.
Yohimbine bara uru iji na-emeso ọrịa akọrọ ọnụ ma ọ bụ xerostomia, ọnọdụ ahụike nke na-ebelata ebe ọnụ ọgụgụ mmiri na-emepụta. Okwesiri ighota ebe a na Acetylcholine na abawanye saliva ma na alpha-2-adrenoceptors na-achịkwa ya. Ndị mmadụ na-arịa xerostomia na-ata ahụhụ site na enweghị acetylcholine na Yohimbine na-enyere ha aka site na ịba ụba acetylcholine.
Ihe a na-elegharakarị anya nke Yohimbine bụ ikike pụrụ iche ọ na-emeso ndị mmadụ n'otu n'otu na ịseụbiga mmanya ókè nke Clonidine, nke bụ ọgwụ ọgwụ edere maka ịgwọ Ntị-deficit / ọrịa hyperactivity(ADHD), ọbara mgbali elu, ọbara mgbali elu, nsogbu nchekasị, na mgbaàmà ọpụpụ.
Yohimbine ya na Naloxone (ọgwụ na-agwọ ọgwụ opioid) na-egosikwa nrụpụta ọrụ iji gwọọ Ọrịa polycystic ovary nke ahụ bụ ọtụtụ mgbaàmà na-eme n'ahụ ụmụ nwanyị nwere oke ogo nke homonụ nwoke (androgens).
Yohimbine Uru maka ndị na-eme egwuregwu na Bodybuilders
A makwaara Yohimbine iji belata ụjọ na-emetụta ụfọdụ ụjọ. Site n'ime nke a, ọ na-enyere ndị na-eme egwuregwu na ndị egwuregwu ndị ọzọ aka ịrị elu na ọsọ ọsọ ma ghọta ebumnuche ha enweghị atụ ma ọ bụ nke a na-enwetabeghị.
Otu uru Yohimbine kachasị na ya mgbe ọ na-abata abụba bụ ike ya iji belata nri na agụụ. Ọ dịkwa mma ịbawanye mmebi abụba n'oge ibu ọnụ ma ọ bụ tupu mmega ahụ. Dị ka a ọmụmụ, Yohimbine supplementation kwa ụbọchị nwere ikike iji belata ogo abụba nke anụ ahụ na ndị na-eme egwuregwu site na 9.3 ruo 7.1 percent.
Nke a kacha mara amara maka imepụta mmetụta ahụike nke ọrịa hyperadrenergic, Yohimbine kachasị mma maka igbutu okirikiri ebe ebumnuche bụ isi nke ndị na-eme egwuregwu na ịkpụ ahụ iji nweta ma ọ bụ melite nkọwa ahụ. Yohimbine bụ ọgwụ magburu onwe ya iji wee nwee ihu ọma ma dọwaa n'ihu asọmpi.
Ọtụtụ anụmanụ na ọmụmụ mmadụ egosila na Yohimbine dị oke nkpa iji wepụ ụjọ nke ụfọdụ ihe, ndị mmadụ, ma ọ bụ anụmanụ site na ịbawanye ogo norepinephrine. Nke a bụ kpọmkwem ihe kpatara eji ọgwụ a eme ọgwụ na-enyekarị ndị ọrịa nwere nsogbu nchekasị nke ọha na eze ọ na-enyere ha aka site na mbenata nchekasị mmekọrịta mmadụ na ibe ya na imeziwanye ọnọdụ.
Ọbụghị naanị nke a, Yohimbine bakwara uru iji meziwanye ncheta ogologo oge site na imezi ogo norepinephrine. Ọgwụ a na-egosikwa nrụpụta ọrụ iji chịkwaa nsị ọbara site na igbochi alpha-2 adrenoceptors na ime ka ntụgharị nke epinephrine gaa norepinephrine. Àgwà ndị a na-eme Yohimbine ọgwụ kachasị mma maka ndị egwuregwu na-etinye aka na egwuregwu dị mgbagwoju anya dị ka chess na egwuregwu ndị ọzọ. Ọzọkwa, Yohimbine na-emekwa ka ndụ dị mma, ùgwù onwe onye, na ntụkwasị obi nke onwe site na ime ka echiche nke ọdịmma dịkwuo mma.
Zụta Yohimbine ugbu a! Nweta SARM kachasị mma site na akara kacha elu SARM UK ụlọ ahịa - The Lọ ahịa SARMs.
Ntụziaka akwadoro nke Yohimbine
Ngwadogwu Yohimbine a tụrụ aro maka ụmụ nwoke bụ 25-50mg kwa ụbọchị, kewara abụọ na obere doses. Ekwesịrị ị drugụ ọgwụ a na nri na ọkacha mma 30-45 nkeji tupu oge mgbatị ahụ, na izu asatọ na izu iri na abụọ. Maka ụmụ nwanyị, usoro ọgwụgwọ Yohimbine a tụrụ aro bụ 10-20mg kwa ụbọchị, kewara ụzọ abụọ hà nhata. Womenmụ nwanyị kwesịrị iji ọgwụ a na-eri ọgwụ a na ọkacha mma 30-45 nkeji tupu oge mgbatị ahụ, n'ime izu asatọ na izu iri na abụọ.
Yohimbine bakwara uru ịgwọ anorgasmia (nke a makwaara dị ka orgasmic dysfunction). Otu nnyocha gosipụtara na usoro 20mg kwa ụbọchị, na 5 mg na-ebuli elu ruo na 50mg kachasị kwa ụbọchị dị mma maka njikwa nke anorgasmia.
Yohimbine Cycle Maka Menmụ nwoke
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izu |
Yohimbine |
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1 |
25mg kwa ụbọchị |
20mg kwa ụbọchị |
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2 |
25mg kwa ụbọchị |
20mg kwa ụbọchị |
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3 |
25mg kwa ụbọchị |
20mg kwa ụbọchị |
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4 |
25mg kwa ụbọchị |
20mg kwa ụbọchị |
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5 |
25mg kwa ụbọchị |
20mg kwa ụbọchị |
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6 |
50mg kwa ụbọchị |
20mg kwa ụbọchị |
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7 |
50mg kwa ụbọchị |
20mg kwa ụbọchị |
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8 |
50mg kwa ụbọchị |
20mg kwa ụbọchị |
|
3 capsules otu ụbọchị |
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9 |
50mg kwa ụbọchị |
20mg kwa ụbọchị |
|
3 capsules otu ụbọchị |
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10 |
50mg kwa ụbọchị |
20mg kwa ụbọchị |
|
3 capsules otu ụbọchị |
|
11 |
50mg kwa ụbọchị |
20mg kwa ụbọchị |
|
3 capsules otu ụbọchị |
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12 |
50mg kwa ụbọchị |
20mg kwa ụbọchị |
|
3 capsules otu ụbọchị |
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13 |
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|
3 capsules otu ụbọchị |
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14 |
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3 capsules otu ụbọchị |
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15 |
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3 capsules otu ụbọchị |
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16 |
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3 capsules otu ụbọchị |
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Atụmatụ na Nlekọta
A naghị akwado Yohimbine maka ụmụaka na ụmụ nwanyị dị ime ma ọ bụ na-enye nwa ara. Ekwesịrị iji ya kpachara anya mgbe ejiri ya na ọgwụ maka ọbara mgbali elu, phenothiazines, ma ọ bụ tricyclic antidepressants. A naghị akwado ogige a maka ndị nwere ọrịa psychiatric na nsogbu akụrụ.
Ọzọkwa, a ga-ahụrịrị nlekọta na ịdị uchu dị elu mgbe a na-enye ndị mmadụ nwere ọgwụ ọgwụ na-arịwanye elu nke ọmịiko ma ọ bụ ndị na-enweta ọgwụgwọ ugbu a na antidepressants tricyclic ma ọ bụ ọgwụ ndị yiri ya nwere ike igbochi metabolism nke norepinephrine ma ọ bụ nnweta neuronal.
Ekwesighi ka emegbu Yohimbine n'ihi na ọ bụ ihe siri ike. Mmegbu Yohimbine nwere ike ibute nsonaazụ dịka ọgbụgbọ, nchekasị, nju anya, na isi ọwụwa. Ejiji Yohimbine ekwesịghị ime yana hemophiliacs yana ndị ekwesịghị ịwa ahụ n'oge na-adịbeghị anya ka ọ ghara iji ya eme ihe n'ihi na ọ na-ebelata nsị. Ejila Yohimbine etinyeghị ihe ndị na-eme ka ọbara dị ka warfarin, aspirin, na heparin.