Yohimbine
Yohimbine, onye alpha-2 adrenergic receptor antagonist, bụ otu n'ime ihe ndị kachasị ewu ewu na mgbatị ahụ, ọkụ ọkụ, na mgbakwunye nri. A na-eji ihe mgbakwunye Yohimbine mee ihe maka ọtụtụ ebumnuche, gụnyere ma ọnweghị oke na-akpali akpali ọnwụ na ịgwọ ọrịa erectile (ED). Yohimbine dịkwa oke irè iji gwọọ nsogbu mmekọahụ bụ nke sitere na ọgwụ ịda mbà n'obi a na-akpọ ndị na-emechi ihe nchịkwa (serotonin reuptake inhibitors (SSRIs)). Ndị na-eme egwuregwu na ndị bodybuilders na-ejikwa ya iji melite arụmọrụ na Yohimbine makwaara iji belata ụjọ metụtara ụfọdụ ụjọ.
Usoro ihe omume nke Yohimbine
Yohimbine na - egbochi alpha-1 na alpha-2 adrenoceptors, na - ebelata ogo serotonin, na - eme ka ogo dopamine na adrenaline dịkwuo elu. A makwaara nke na-ebelata shuga shuga, na-ahapụ insulin, ma na-eme ka ọbara mgbali elu. Ọ na - eduga n'ịgbasa arịa arịa ọbara nke nwoke na nwanyị na ntinye ọhụụ ọhụrụ na anụ ahụ. A makwaara Yohimbine iji mee ka ihe na-agbanwe agbanwe na mpaghara nke eriri afọ. A maara ya nke ọma maka igbochi ihe nnabata serotonin, igbochi ọwa calcium, na mmetụta monoamine oxidase na-egbochi ya.
Yohimbine na-egbochi ndị na-anabata mkpụrụ ọgwụ presynaptic alpha-2 adrenergic ọtụtụ na mpaghara nke Reserpine ọ bụ ezie na ihe ọ na-eme bụ maka obere oge na ike ọgwụgwụ. Mmetụta ụbụrụ autonomic dị n'akụkụ nke Yohimbine bụ iji belata ọmịiko (adrenergic) ma mụbaa ọrụ parasympathetic (cholinergic). Okwesiri icheta ebe a na mmekorita nwoke na nwanyi nwere mmekorita ya na oru nkpuchi nke alpha-2 nke nwere ike ibute onu ogugu ma obu karia.
Hapụ ụlọ ahịa abụba dị isi ike dị ka nri gị na-abụkarị usoro siri ike n'ihi ọtụtụ ihe. Ọ bụghị ihe ijuanya na ọtụtụ n’ime anyị hụrụ nwere ụfọdụ mpaghara “isi ike” ma ọ bụ anaghị adị mfe ịhapụ abụba jọrọ njọ [na-abụkarị obere abs, gbadaa ala, na ukwu maka ụmụ nwoke na ụkwụ na hips maka ụmụ nwanyị]. Ọtụtụ mgbe, nke a bụ n'ihi ọnụ ọgụgụ dị elu nke ndị Alfa-2 Rekọb na mkpụrụ ndụ abụba na-agwa ahụ ka ọ jigide abụba na mpaghara ndị a maka ebumnuche lanarị. Yohimbine na-egbochi ndị nabatara Alpha-2 a wee si otú a gbuo ozi ahụ iji jigide abụba ahụ dị isi ike. Ọ na-emekwa ka abụba na-agbapụta maka oxidisation (ọkụ).
Mmekọrịta Enzymatic
Yohimbine nwere ikike ịmekọrịta enzyme CYP2D6 ma gbochie ọrụ ya. Nnyocha e ji atụle Ki kwuru ihe pụtara Ki nke 0.52uM maka ọcha CYP2D6 enzymes na 0.23uM maka microsomes. Nke a gbatịrị Corynanthine nwere otu Ki nke 0.08uM. Okwesiri ighota ebe a na nke a bu otu enzyme nke na-eme ka Yohimbine banye 11-hydroxy Yohimbine ma gosiputa ihe di iche nke 1000 n'etiti ndi mmadu dabere na CYP2D6 kwuputara genotype (ya na obere mkparita uka na CYP3A4).
Uru Yohimbine bara
- Yohimbine na-enyere aka n’ịchọsi agụụ ike.
- Ọ na-enyere aka ịlụ ọgụ abụba afọ isi ike.
- Yohimbine na-ebelata oke abụba na-enweghị mmetụta na-adịghị mma na-emetụta oke ahụ dị oke mkpa maka ịhazi ahụ ahụ.
- Ọ na - eme ka mmega ahụ dịkwuo mma site na ịhapụ ike ọgwụgwụ anụ ahụ nke bụ ihe dị mma naanị n'ihi na arụmọrụ mgbatị nwere ike belata n'ihi ụkọ calorie.
- Yohimbine na-eme ka metabolism dịkwuo mma maka ahụmịhe na-ere ọkụ.
- Ọ na - eme ka ntachi obi na ike dịkwuo mma.
- Yohimbine abụghị nke abụọ maka ogwe aka dị isi ike, njikwa ịhụnanya, ịmị mkpụrụ (na) na abụba apata.
- Yohimbine na-arụ ọrụ dị ka ezigbo onye na-ebelata agụụ.
- Njirimara ndị na-akpali akpali dị egwu nke Yohimbine na-eme ka ọ bụrụ nnukwu nhọrọ maka ndị na-eme egwuregwu, na-apụ na ubi.
- Ọbụghị naanị nke a, Yohimbine na-eme ka mmụba nke agụụ mmekọahụ, ọchịchọ, ugboro ole na-enwe mmekọahụ, na ogo nke nrụpụta n'oge na-enwe mmekọahụ.
- Ọ na-ebelata ma mgbaàmà anụ ahụ na nke mmụọ na-ejikọkarị na nrụrụ erectile.
Adrenergic Neurotransmission
Usoro nyocha kachasị na nke bụ isi nke Yohimbine bụ inactivation (antagonism) nke klaasị ndị natara akpọrọ Alpha-2-Adrenergic receptors. Yohimbine na-egbochi ndị a autoreceoptors na presynaptic noradrenergic neurons iji mee ka ntọhapụ nke noradrenaline dị ka mmeghachi omume mmechi nzaghachi na-adịghị mma.
Yohimbine na Egwu mkpochapu
Yohimbine nwere ikike pụrụ iche iji kwado mbibi egwu nke bụ ihe omume mmụọ ebe ọhụụ na-aga n'ihu na ihe mkpali na-atụ egwu na-edugakarị na-enweghị ihe ọ bụla na-akpata nsogbu ahụ ma belata ma ọ bụ wepụ ụjọ metụtara ya. Ọ bụ n'ihi nke a ka e ji jikọọ Yohimbine na egwu egwu mkpochapụ nke abụọ na usoro ọgwụgwọ.
Yohimbine na abụba abụba
Yohimbine na - arụ ọrụ sistemu adrenergic nke sel ndị na - edozi thermogenesis. A na-ahụ beta-subunits nke ndị na-anabata adrenergic, nke bụ ebumnuche nke ephedrine, dị ka ihe na-akpali abụba abụba na-akpali akpali ka ha na-eme ka ọrụ Adenyl Cyclase (enzyme) na nke na-esote Cyclic adenosine monophosphate [(ihe mgbakwasị ụkwụ nke adenosine triphosphate (ATP)) etoju .
Okwesiri icheta ebe a na mkpụrụedemede mkpụrụedemede na-egbochikwu usoro nke metabolism abụba. Yohimbine, ịbụ onye na-ahọta alpha-2 adrenergic receptor antagonist (inactivator), na-egbochi mmalite nke ihe nnabata na-egbochi ma na-echekwa ọrụ nke Adenyl Cyclase na mmetụta mgbasa ozi site na ndị nabatara beta.
Etu esi ewere Yohimbine?
N'ozuzu, Yohimbine kachasị mma iji ọgwụ 0.2 mg kwa kilogram nke arọ ahụ mee ka abụba gbaa. Nke a ga - apụta usoro 14mg maka mmadụ 150lb ma ọ bụ 18 mg maka q 200lb onye ọ bụla. Ọ dị mkpa iburu ebe a na mgbakwunye Yohimbine kachasị dị irè n'oge ebu ọnụ ma ọ bụ n'etiti nri. Ọ bụrụ na ị nwere obi abụọ ọ bụla ma ọ bụ mgbagwoju anya banyere ezigbo usoro ọgwụgwọ Yohimbine, ọ ka mma ka gị na dọkịta ma ọ bụ ụlọ ahịa ọgwụ kacha nso dị nso karịa ịnara usoro ọgwụgwọ Yohimbine na-ezighi ezi.
Dị ka o kwesịrị, Yohimbine kachasị edozi tupu ebuo cardio. Insulin na-akụda mmetụta nke Yohimbine na Alpha-2 Ndị nabatara. Ya mere, iri nri na-eji Yohimbine agaghị aba uru ọ bụla na ọ bụ ihe dị mma mgbe niile iji ebu ọnụ ọ dịkarịa ala awa 3-4 tupu iji Yohimbine eme ihe. Nke abuo, achọrọ ka abụba gbaa ọkụ mgbe emechiela ndị Alpha-2. Nke a pụtara na ahụ kwesịrị ịrụ ọrụ ụfọdụ yana ọ nweghị ọrụ ka mma karịa kaadi ngwa ngwa.
Ichekwa Yohimbine
Yohimbine nwere ike ịdọrọ ya na ndị na-emepụta ihe na-emepụta etrogen androgen modulators dị ka Ostarine(MK-2866), Ibutamoren(MK-677), Andarine(S-4), LGD-4033, na Cardarine(GW-501516).
Nchịkọta nke GW-501516 na Yohimbine bụ ihe pụrụ iche karịa naanị otu ụzọ. Cardarine dị mma iji banye n'ime mgbatị ndị dị na njikere ma melite ntachi obi. Ọ dịkwa irè iji kpochapụ mmetụta nke ịmịcha mmiri n'oge mgbatị siri ike n'ihi nnukwu obi na obere carbs. N'ikwu ya n'ụzọ ọzọ, Cardarine na-enyere gị aka ịme ihe ndị ọzọ na-ebu ibu dị arọ n'ụzọ ka mma. Ọ bụrụ na nke ahụ abụghị ihe niile, ọ na-agbanwe ike kachasị mma nke ahụ site na glucose (carbohydrates) na abụba nke pụtara na ị ga-ewepu abụba karịa ụbọchị niile. Nke a pụtakwara na a ga-enwe ọtụtụ glycogen echekwara maka mgbatị ahụ kpụ ọkụ n'ọnụ n'ọdịnihu. N'aka nke ọzọ, Yohimbine doro anya karịa GW-501516.
Mgbochi / Nlekọta
A na-egbochi Yohimbine nye ndị nwere ahụike ahụike ma ọ bụ na-alụ ọgụ ugbu a na nsogbu ahụike dịka nchekasị, ịda mbà n'obi, hypotension, angina, ọrịa akụrụ, ma ọ bụ ọrịa imeju. A naghị atụ aro ya nye ụmụ nwanyị dị ime ma ọ bụ ndị na-enye nwa ara na ọbụna ụmụaka. E kwesiri iji nlezianya mee Yohimbine ma ọ bụrụ na ị na-arịa ọrịa shuga, schizophrenia, ọbara mgbali elu, ma ọ bụ hyperplasia prostatic.
Ọ dị mkpa iburu n'uche na Yohimbine gosipụtara mmetụta mgbakwunye na ndị na-emechi monoamine oxidase. Yohimbine nwere ike belata ma ọ bụ mee ka ọbara mgbali elu dị na tricyclic antidepressants.
Ngwunye ogwu nke Yohimbine ekwesighi ka abawanye ma ọ bụ mebie ya n'oge ọ bụla n'olileanya nke nsonaazụ ngwa ngwa. Mmegbu nke Yohimbine nwere ike ibute nsonaazụ dịka itching, dizziness, na mmeghachi omume nfụkasị. Ojiji nke Yohimbine kwesiri ka o soro gi site na nkwenye ndi okacha amara.
Etu esi azuta Yohimbine?
Ọ bụrụ na ị na-achọ ka zụrụ Yohimbine, anyị na-akwado ịhọrọ naanị onye ama ama Yohimbine na-ere ahịa dị kaLọ ahịa SARMs. Nke a bụ naanị n'ihi na ọtụtụ ndị na-ere ahịa Yohimbine adịgboroja na ịtụkwasị ha obi ga-apụta na ọ bụghị naanị na ị ga-efunahụ ego ị tara ahụhụ, kamakwa ị na-ekpughe ahụ gị na ngwaahịa adịgboroja, nke a na-agbanyeghị, ma ọ bụ nke obere.
Maka nke a, a na-atụ aro ya mgbe niile ịgụ nyocha, nzaghachi, aro, na mkpesa (ma ọ bụrụ na ọ bụla) site na nzukọ na-agbakwunye na mgbakwunye mgbakwunye dị iche iche. Nke a ga - enyere gị aka ịmata ndị kacha ere ahịa Yohimbine ma họrọ ihe mgbakwunye Yohimbine kachasị mma iji kwado ahụ gị, ahụike, na ahụike gị, ihe ị chọrọ., Ọzọkwa, ọ ga - enyere gị aka ịme mkpebi akọwapụtara iji nọrọ na nchedo pụọ na nsogbu nke mmegbu Yohimbine. Cheta, ọ ka mma ka ịnwe nchedo ma jiri Yohimbine maka mgbakwunye mgbakwunye gị abụghị otu.